Cerebellar Purkinje cell (De Schutter and Bower 1994)

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Contributor:NIJC Administrator (nijcadmin)  |  Created Date: Jun 21, 2011 19:11:40  |  Visits:3291  |  Runs:387
Free Keywords: Cerebellum, Purkinje cell, Multi-compartment, Realistic
ID 416
Title Cerebellar Purkinje cell (De Schutter and Bower 1994)
Free Keywords Cerebellum, Purkinje cell, Multi-compartment, Realistic
Description README file for the Tutorial simulation of a cerebellar Purkinje cell

This tutorial is based upon a GENESIS simulation of a cerebellar Purkinje
cell, modeled and fine-tuned by Erik de Schutter. The tutorial assumes that
you have a basic knowledge of the Purkinje cell and its synaptic inputs. It
gives visual insight in how different properties as concentrations and
channel conductances vary and interact within a real Purkinje cell.

In order to run the simulation, you need the following :

1) A fast computer (Pentium200 or SPARC20) with enough memory installed (at
least 32Mb - 64Mb, depending on which and how many programs are running)

2) Genesis 2.2 installed and correctly configured.

3) A graphical display with at least a resolution of 1024*768

4) the UNIX shell commands : sort, touch

To explore the tutorial, do the following :

1) Make room for the graphical output : move your shell window to the lower
right hand corner of your display.

2) Change to the directory where the TUTORIAL.g script resides. If you are
reading this file, you should be in the correct directory. The tutorial
will create some files in this directory, so you will need to have write
privileges. If the tutorial is installed in a system directory for which
you do not have write permission, copy the tutorial files to a directory
in which you are allowed to create files.

3) At the shell prompt, type "./TUTORIAL". (This Unix shell script will
create any needed files and will start GENESIS using the TUTORIAL.g
script. You do not need to start GENESIS yourself.) After a long
initialization period, a window with a Purkinje cell and a control panel
will appear. To move on, click the 'Help' button in the control panel.
This will popup the on-line help window. These instructions, which you
will need to read before running the tutorial, are contained in the file

Ambitious users can run this tutorial using different model setup files
(all the files titled Purk_*, including the morphology file, can be
changed). Before you do so you need to reconfigure the simulation by
running "genesis makeconfig.g". After some diagnostic messages, you
should return to the shell prompt.

For feedback write:
Concepts and documentation: Erik de Schutter
Bugs: Hugo Cornelis

Consult our webpages at bbf-www.uia.ac.be for relevant publications and
additional documentation concerning the model scripts.

Copyright for all the scripts: Born-Bunge Foundation - UA 1998-1999.
Last Modified Date Mar 21, 2013 10:59:04
Created Date Jun 21, 2011 19:11:40
Contributor NIJC Administrator (nijcadmin)
Item Type Online Simulation
Change Log(History)
Mar 21, 2013 Modified; Contents URL.
Feb 12, 2012 Modified; Description.
Feb 12, 2012 Modified; Description.
Model Contents URL http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=7176
Model Site Name ModelDB
Simulator Name Genesis
Simulator Version
/ Public / Title / A-E

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